MyBioSource.com's BRAP Antibody is a Mouse monoclonal antibody. The BRAP Antibody was generated using BRAP as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Western Blot.
Description
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport